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Neurosci Biobehav Rev Iyer KS et al

When we looked at effectiveness, a daily dose of 600mg of racemic ALA (a 50/50 mix of R- and S-isomers) stood out

Its dual route of administration, oral and intravenous, provides dosing flexibility, which is particularly beneficial for long-term outpatient management

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It is generally spread through the bite of phlebotomine sandflies, Phlebotomus and Lutzomyia, and occurs most frequently in the tropics and sub-tropics of Africa, Asia, the Americas, and southern Europe